Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2108H3374N526O649S18

DescriptionStandard

        MLSLCCILALLALSCPETSGNTAGVKVKLTQKGLEYGRQIGVTTLLDQFKTIKVPDFSGSEEVSPIGKVSYSLTGIKVINVGLPQSEVALVPGTGVSLTITEKHANIFCANSKSPAYSYIKDEGENGSFDLAVSELSISTTVTIQSDDTGRPVVSSANCAASVGQTSVTFHGGASWLYNLFSSYIDDALRSVLQRKICPLVSEAIDKMNPYLKTLNVLAKVDQYAEIDYSMVESPVISTSSIDLSFNSAGFVYNNAGALSLRITDDMIPSSSPFRLNTKTFGTFIPQIAKQYPDLMMELLVKAATAPTVMFTPNNITLQANATVTAYAIQPNTTLTPLFILNVDASVSCQIYVTGVKVAGNLTLNAVNMTLGTSYVGPFEVKSLDSIFQMVLKAAVIPEVNALLQQGFPLPAIGEMNLVNTQLVIMKDYLLIGTDVQFTA
    

Molecular Weight47047.64 Da

Isoelectric Point (pI)4.94

Net Charge (pH 7.0)-8.36

Net Charge (pH 7.4) -8.88

Charge Density (pH 7.0) -0.0190

GRAVY Index0.28

Hydrophobic Moment 0.70

Boman Index0.20

Instability Index32.09

Aliphatic Index 103.23

Aromaticity 0.0750

Extinction Coeff. Reduced 27850.00

Extinction Coeff. Oxidized 28225.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0201238 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence