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MYP_144132
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Basic Information
AMP 1A analogs6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXGXKXGXFXGXGKXKKKK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044544 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus anthracis NR-3838
10.33 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0048720 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pneumoniae ATCC 49619
45 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0051095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
Acetylation
Amidation
X(3/7/11)=A6c (1-aminocyclohexane carboxylic acid); X(5/9/13/16)=Oic (Octahydroindolecarboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: NCI-H69
5.9 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0051249 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
A6c = 1-aminocyclohexane carboxylic acid, Oic = Octahydroindolecarboxylic acid
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis H37Rv
20.92 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0055752 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Burkholderia pseudomallei NCTC 8016
45 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
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