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MYP_144132
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Basic Information
AMP 1A analogs6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXGXKXGXFXGXGKXKKKK
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0180339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
Tic = Tetrahydroisoquinolinecarboxylic acid, A6c 1-aminocyclohexane carboxylic acid
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis H37Rv
10.33 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0181885 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Clostridioides difficile ATCC 43255
1.4 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0185061 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus USA 300
45 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0186752 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
Acetylation
Amidation
X(3/7/11)=A6c (1-aminocyclohexane carboxylic acid); X(5/9/13/16)=Tic (Tetrahydroisoquinolinecarboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
7.5 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0192943 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
contains non-canonical/unspecified residues (X); stereochemistry not fully specified [Other]
unspecified non-canonical residue at 3,5,7,9,11,13,16
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
43 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
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