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MYP_144064
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Basic Information
A56
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
20 amino acids
C91H153N21O27S2
Standard
Sequence
PVLQPALSLSCGPEPLLLSC
Physicochemical Analysis
2037.44 Da
4.05
-1.06
-1.15
-0.0529
0.88
0.26
0.37
105.61
136.50
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
716.94
-5.90
25.0
28.0
60.0
141.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011327 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Human cytomegalovirus (Replication); HeLa
40 %
GFP assay
PaperInhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84. | Kaiser N, Lischka P, Wagenknecht N, Stamminger T. | J Virol. 2009 | PMID:19740994 PMID19740994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19740994/
RECORD: Rec_0059426 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 60.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0148480 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19740994 PMID19740994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19740994/
RECORD: Rec_0211517 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human cytomegalovirus(HCMV):inhibition of virus replication in HeLa cells
40 %
Inhibition
PaperPubMed PMID: 19740994 PMID19740994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19740994/
RECORD: Rec_0390803 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCMV Replication inhibition
Human cytomegalovirus(HCMV) | HeLa cells
Mammalian: >20 h; Yeast: >20 h; E. coli: ?
PaperInhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84. | Kaiser N, Lischka P, Wagenknecht N, Stamminger T. | J Virol. 2009 Nov;83(22):11902-13. | DOI:10.1128/JVI.01378-09 | PMID:19740994 PMID19740994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19740994/