Peptide Database

Peptide NameNivolumab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2154H3334N576O665S16

DescriptionStandard

        QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
    

Molecular Weight48452.01 Da

Isoelectric Point (pI)7.96

Net Charge (pH 7.0)2.39

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0054

GRAVY Index-0.41

Hydrophobic Moment 0.55

Boman Index-0.00

Instability Index46.78

Aliphatic Index 69.86

Aromaticity 0.0955

Extinction Coeff. Reduced 76320.00

Extinction Coeff. Oxidized 76945.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253726 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-Life26.7 days