Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2386H3798N618O673S16

DescriptionStandard

        MARGPDNTPRWAALMVLAALGTAVTETTNPGIVARITQKGLDYARQQGVATLRRELGKIEIPAFSGSFKIKYLGKGEYNFYSLVIREVQLPSSQIRLLPNEGLALSVTDASVKISGKWKARKNFIKTSGDFVLSVQGVSIAAGLKLSCDPASGHSTVACSSCSNHIDSIRVHVSGSHLGWLIQLFHKKIESSLQKALSSKICQVVAKSVSSKLEPFFQTMPVTAKIDKVAGIDYSLLAPPIATTETLDGQLKGEFFSLAHRSPPPFAPPALALPMDHDHMVYLGISDYFFNTAGLVYQQAGALNLTLKDDMIPKKSKFHLTTKYFGTLIPKLAKMFPNMSMQFLIRVSSPPHLTVSPAGLACTPTLEAQAFAVLPNSSLAPLFLLGMSTNASVEVGAVSDRLVGELSLDKLLLELKHSDIGPFSVELLQAVMNYIVPTTVLPKVNERLQKGYPLPLPADVQLFNLVLQSYQNFLLFGADVLYH
    

Molecular Weight52422.46 Da

Isoelectric Point (pI)9.19

Net Charge (pH 7.0)10.52

Net Charge (pH 7.4) 9.52

Charge Density (pH 7.0) 0.0218

GRAVY Index0.16

Hydrophobic Moment 0.72

Boman Index0.15

Instability Index37.42

Aliphatic Index 102.17

Aromaticity 0.0807

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0179905 VERIFIED: NO

Provenance & Taxonomy

OrganismPipistrellus kuhlii [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria