Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2320H3659N599O650S12

DescriptionStandard

        MAVQSLAPAALLLAVSITLARATKPGIVARITGPGLDYALQKGISALEKKLAEMKLPDISGSQETPVGDVYYEFSRLNLRSFRLPSSQITPLPDVGVQVSVSNAFAQLTGNWRWKRGLFGDDGQFNLKVTGLSISVGLQLGRDASGKPTVTASGCTTCISDVDVDAGWIYKLIIKIIKSHIKALMQSQVCREVRSFVSTQLQPYLHALPVTAAIDTVAGVDYSLVAFPVATAQYVDVSLKGEIFSRAHRAPAPFSPPALAFPPEHGRMVYLGVSSYVFNTASFVYQAAGCLVFSITDDVFPKEGFFHLNTSTFYHFVPQLKQRYPDRLMKLQLTTPSAPFLTIAPGGLELALVADVQAYAILPNASLTPLFLLHLTSNVSASVTVSSARICGALASGGLELSLKHSDIGPFPVLGLQQFMNFLASNILLPLVNGKLEKGFPLPLPAHVQLSSCVLQPHQDFLLLGADVRYGL
    

Molecular Weight50727.27 Da

Isoelectric Point (pI)8.77

Net Charge (pH 7.0)5.33

Net Charge (pH 7.4) 4.44

Charge Density (pH 7.0) 0.0113

GRAVY Index0.31

Hydrophobic Moment 0.73

Boman Index0.20

Instability Index36.32

Aliphatic Index 106.00

Aromaticity 0.0890

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37735.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424534 VERIFIED: YES

Provenance & Taxonomy

OrganismAlligator mississippiensis [Animal]

FamilyBPI/LBP

Tax ID8496

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria