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MYP_143932
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Basic Information
VV-hemorphin-7
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
9 amino acids
C59H82N14O13
Standard
Sequence
VVYPWTQRF
Physicochemical Analysis
1195.37 Da
8.72
0.73
0.52
0.0814
-0.14
0.46
0.12
-14.06
64.44
0.3333
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
448.57
-1.08
16.0
14.0
32.0
86.0
5.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018567 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Hemorphin
9913
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
250 μM
Equivalent bitterness assay
PaperBitter peptide from hemoglobin hydrolysate: isolation and characterization. FEBS Lett., 364, 115-119, 1995 PMID7750554 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7750554/
RECORD: Rec_0018716 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]; Bos taurus [Animal]; Mus musculus [Animal]
9823, 9913, 10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Taste Toxin Enzyme inhibitory
34.3 μM
IC50
RECORD: Rec_0026153 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
5.5 μM
IC50
PaperA new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides. PMID23194537 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23194537/
RECORD: Rec_0035457 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID11237710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11237710/
RECORD: Rec_0046488 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Hemorphin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
34.3
PaperZhao Q., Sannier F., Garreau I., Guillochon, Piot J. M.. Inhibition and inhibition kinetics of angiotensin converting enzyme activity by hemorphins isolated from peptic bovine hydrolysate. Biochem. Biophys. Res. Commun., 204, 216-223, 1994.
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