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MYP_143908
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WWVXARAXRR
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022507 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Valerylamide (N-acylation)
Amidation
(S)-2-(4-pentenyl)-alanine at positions 4 and 8; oct-4-enyl hydrocarbon staple between positions 4 and 8
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans 002 ATCC 64385
>20 μM
MIC
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0029847 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Valerylamide (N-acylation)
Amidation
(S)-2-(4-pentenyl)-alanine at positions 4 and 8; oct-4-enyl hydrocarbon staple between positions 4 and 8
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
0.63 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0041900 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Valerylamide (N-acylation)
Amidation
(S)-2-(4-pentenyl)-alanine at positions 4 and 8; oct-4-enyl hydrocarbon staple between positions 4 and 8
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Enterococcus faecalis ATCC 29212
5 μM
MIC
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0051058 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Valerylamide (N-acylation)
Amidation
(S)-2-(4-pentenyl)-alanine at positions 4 and 8; oct-4-enyl hydrocarbon staple between positions 4 and 8
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 700926
38.3 μM
IC50
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
RECORD: Rec_0052802 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Valerylamide (N-acylation)
Amidation
(S)-2-(4-pentenyl)-alanine at positions 4 and 8; oct-4-enyl hydrocarbon staple between positions 4 and 8
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 700926
20 μM
MIC
PMID28073163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28073163/
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