Peptide Database

Peptide NameNeutrophil antibiotic peptide NP-1 (RatNP-1) (Neutrophil defensin 1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC440H725N135O138S8

DescriptionStandard

        MRTLTLLTALLLLALHTQAKSPQGTAEEAPDQEQLVMEDQDISISFGGDKGTALQDADVKAGVTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
    

Molecular Weight10370.81 Da

Isoelectric Point (pI)8.27

Net Charge (pH 7.0)1.54

Net Charge (pH 7.4) 1.17

Charge Density (pH 7.0) 0.0164

GRAVY Index-0.28

Hydrophobic Moment 0.63

Boman Index-0.10

Instability Index32.69

Aliphatic Index 81.06

Aromaticity 0.0532

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4450.07

LogP -50.80

H-bond Donors 165.0

H-bond Acceptors 149.0

Rotatable Bonds 351.0

Heavy Atoms 721.0

Ring Count 8.0

Amide Bonds 99.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0094605 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus