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MYP_143770
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Basic Information
Endothelin-2
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
21 amino acids
C116H165N27O32S4
Standard
Sequence
CSCNSWLDKECVYFCHLDIIW
Physicochemical Analysis
2577.97 Da
4.54
-2.19
-2.51
-0.1043
0.37
0.30
0.22
56.15
88.10
0.1905
12490.00
12740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
947.28
-4.94
37.0
35.0
79.0
179.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0193593 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0270383 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
Endothelin/sarafotoxin
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Vasoactive Hormone
Evidence URLhttps://www.uniprot.org/uniprotkb/EDN2_RAT/entry
RECORD: Rec_0312488 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Endothelin
10090
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory ACE inhibitory
Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
RECORD: Rec_0359829 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
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