Peptide Database

Peptide NamePleurocidin from Pleuronectes americanus

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC131H195N37O30

DescriptionStandard

        GWGSFFKKAAHVGKHVGKAALTHYLG
    

Molecular Weight2768.18 Da

Isoelectric Point (pI)10.18

Net Charge (pH 7.0)4.02

Net Charge (pH 7.4) 3.65

Charge Density (pH 7.0) 0.1545

GRAVY Index-0.08

Hydrophobic Moment 0.59

Boman Index0.20

Instability Index5.17

Aliphatic Index 67.69

Aromaticity 0.1538

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1057.42

LogP -7.90

H-bond Donors 38.0

H-bond Acceptors 37.0

Rotatable Bonds 89.0

Heavy Atoms 198.0

Ring Count 8.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0322400 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyPleurocidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic Antimicrobial Antifungal

TargetCandida albicans, Saccharomyces cerevisiae and Trichosporon beigelii (target not resolved to a single organism)

Activity2.5 μM

MethodMIC (lowest reported value in antifungal panel)