Peptide Database

Peptide NameNeutrophil defensin 1 (Defensin, alpha 1; primates, mammals, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antifungal

Antiviral

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC150H228N44O38S6

DescriptionStandard

        ACYCRIPACLAGERRYGTCIYQGRLWAFCC
    

Molecular Weight3448.08 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.45

Charge Density (pH 7.0) 0.0912

GRAVY Index0.28

Hydrophobic Moment 0.49

Boman Index0.06

Instability Index62.13

Aliphatic Index 65.33

Aromaticity 0.1667

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10345.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1323.13

LogP -10.92

H-bond Donors 55.0

H-bond Acceptors 47.0

Rotatable Bonds 105.0

Heavy Atoms 238.0

Ring Count 7.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359475 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Antiviral

RECORD: Rec_0409252 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)