Peptide Database

Peptide NameSLAY-screened peptide P650

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC86H141N25O25

DescriptionStandard

        PLKVPNASNNLVRFTSPA
    

Molecular Weight1925.19 Da

Isoelectric Point (pI)11.01

Net Charge (pH 7.0)1.96

Net Charge (pH 7.4) 1.90

Charge Density (pH 7.0) 0.1087

GRAVY Index-0.20

Hydrophobic Moment 0.66

Boman Index0.02

Instability Index45.82

Aliphatic Index 86.67

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 804.33

LogP -9.85

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 58.0

Heavy Atoms 136.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0222004 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/