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MYP_143526
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Uric acid metabolism ▸ Hypouricemic activity
Standard
2 amino acids
C15H18N4O4
Standard
Sequence
YH
Physicochemical Analysis
318.33 Da
6.74
-0.15
-0.41
-0.0769
-2.25
0.26
-0.07
66.70
0.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
141.33
-0.20
5.0
5.0
7.0
23.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024984 VERIFIED: NO
Provenance & Taxonomy
Undaria pinnatifida [Plant]
74381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperAntihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats PMID15135150 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15135150/
RECORD: Rec_0030724 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
PaperLan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.. Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015. PMID25577052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25577052/
RECORD: Rec_0039017 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Enkephalin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-III Inhibitory
PaperLee, C.M.; Snyder, S.H.. Dipeptidylaminopeptidase-III of rat brain selective affinity for enkephalin and angiotensin. J. Biol. Chem., 257, 12043-12050, 1982.
RECORD: Rec_0058154 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
5.29 pIC50
pIC50
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach. PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
RECORD: Rec_0161564 VERIFIED: YES
Provenance & Taxonomy
Undaria pinnatifida [Protist]
ACE-inhibitory peptide
74381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
5.1 μM
IC50
PaperAntihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats PMID15135150 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15135150/
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