Peptide Database

Peptide NameBrevinin-1Pd

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC121H196N28O29S2

DescriptionStandard

        FLPIIASVAANVFSKIFCAISKKC
    

Molecular Weight2571.15 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.1141

GRAVY Index1.32

Hydrophobic Moment 0.60

Boman Index0.40

Instability Index14.07

Aliphatic Index 122.08

Aromaticity 0.1250

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 905.67

LogP -5.50

H-bond Donors 33.0

H-bond Acceptors 34.0

Rotatable Bonds 83.0

Heavy Atoms 180.0

Ring Count 4.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0173981 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyBrevinin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetGram-positive bacterium: Staphylococcus aureus

Activity27 μM

MethodMIC

RECORD: Rec_0192170 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

RECORD: Rec_0233594 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyBrevinin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

RECORD: Rec_0244736 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

RECORD: Rec_0251129 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates pipiens [Animal]

FamilyBrevinin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity78.0 μM

MethodMIC

PaperJ. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/

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