Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2233H3551N569O659S17

DescriptionStandard

        MTGKSMSLWCVTVALLGLLTPALSTDPGVIVQLTQQGLEYGRQIGIASLQQKLNSIKIPDISGSEDVSPIGKVEYSLSQMHITNLGLPASSLGLVPGSGLSLSISDAFISLNGHWHVKYLKFIKDSGSFDLTVSGLTISVTMGVNSDETGRPTVSSSNCAASVGHVSIEFHGGKTSICPLVHDAISDINPHLKTMNVLAQVDKYAEIEYSLVTSPVVSNTFIQFSLKGEFYKIGQHQEPPFSAPPFSLPQTNGSMLYLGLSSFIANSAGFVYHNAGVLGLYVTDDMIPSSSPLRLNTKTFGAFIPEIAKRFPNMMMKLLVKTLEPPRITFEPNNVTLQANGTVTAYAILPNNTLEALFILNLEASVSAELHVSGLNIAGSVTLNRISMTLGTSYVGQFQVMPLNNIFTMILKVVVIPKVNEKLQQGYPLPAISHMNLVNTQLKVLKDYILVGTDVHFTQ
    

Molecular Weight49457.60 Da

Isoelectric Point (pI)6.45

Net Charge (pH 7.0)-2.46

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.0054

GRAVY Index0.23

Hydrophobic Moment 0.70

Boman Index0.21

Instability Index34.36

Aliphatic Index 104.64

Aromaticity 0.0741

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0100754 VERIFIED: NO

Provenance & Taxonomy

OrganismScleropages formosus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence