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MYP_143399
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Basic Information
C41 [E18X](E18C)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
41 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EWDREINNYTSLIHSLIXESQNQQEKNEQELLELDKWASLW
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028520 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 18 indicates PEG750-Cys
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cell-cell fusion between CHO-WT cells and K652 cells
0.0045±0.001 μM
IC50
PaperPubMed PMID: 22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0067983 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 18
Bio-Activity Profile
Antiviral
HIV-1
PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0151453 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 18 indicates PEG2000-Cys.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CHO-WT cells; K652 cells
0.0049±0.0006 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0188745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 18 indicates PEG750-Cys
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0202831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 18 indicates PEG2000-Cys
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
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