Peptide Database

Peptide NamesacB signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC135H220N34O37S

DescriptionStandard

        MNIKKFAKQTVLTFTTALLAGGATQAFA
    

Molecular Weight2943.46 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)2.50

Net Charge (pH 7.4) 2.28

Charge Density (pH 7.0) 0.0892

GRAVY Index0.53

Hydrophobic Moment 0.49

Boman Index0.26

Instability Index33.84

Aliphatic Index 87.50

Aromaticity 0.1071

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1157.50

LogP -11.11

H-bond Donors 40.0

H-bond Acceptors 41.0

Rotatable Bonds 98.0

Heavy Atoms 207.0

Ring Count 3.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0256010 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization alpha-amylase (AmyS) secretion

TargetBacillus subtilis 1A751p

Activity1019.1 U/mL

MethodAmylase activity assay

PaperFu G, Liu J L, Li J S, et al. Systematic Screening of Optimal Signal Peptides for Secretory Production of Heterologous Proteins in Bacillus subtilis[J]. Journal of Agricultural and Food Chemistry, 2018, 66(50): 13141-13151. PMID30463403 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30463403/