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MYP_143366
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological regulation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C9H18N2O4
Standard
Sequence
SL
Physicochemical Analysis
218.25 Da
5.24
-0.54
-0.75
-0.2700
1.50
0.55
0.44
5.00
195.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
-1.08
4.0
4.0
6.0
15.0
0.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0085510 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Model sensory peptide
32630
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
PaperQuantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem., 30, 1873-1879, 1987
RECORD: Rec_0190628 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
2517.08
IC50
PaperNongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.. Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653, 2013.
RECORD: Rec_0241478 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial
recombinant Escherichia coli surface-display screening
SLAY screening
PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/
RECORD: Rec_0263972 VERIFIED: YES
Provenance & Taxonomy
Neobellieria bullata,Sarcophaga bullata [Animal]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory DPP-IV Inhibitory
Dipeptidyl peptidase IV
2517.08 ± 36.33 μM
IC50
RECORD: Rec_0304353 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperThree-dimensional holograph vector of atomic interaction field (3D-HoVAIF): a novel rotation-translation invariant 3D structure descriptor and its applications to peptides. PMID17654623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17654623/
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