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MYP_143339
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
33 amino acids
C142H253N41O44S4
Standard
Sequence
GIMDTLKNLAKTAGKGALQSLVKMASCKLSGQC
Physicochemical Analysis
3367.04 Da
9.60
3.74
3.50
0.1132
0.15
0.66
0.08
33.24
91.82
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1392.34
-16.92
50.0
52.0
121.0
231.0
0.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226738 VERIFIED: YES
Provenance & Taxonomy
Rana ridibunda [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
shows hemolytic activity
Hemolysis
PaperBrevinin - 2Ef Evidence URLhttps://www.uniprot.org/uniprotkb/P86153/entry
RECORD: Rec_0288450 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
0.5 μM
MIC
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0314476 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperM.F. Ali et al. / Peptides 24 (2003) 955-961. Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex Evidence URLhttps://www.uniprot.org/uniprotkb/P40842/entry
RECORD: Rec_0391859 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSimmaco M., Mignogna G., Barra D., Bossa F.;. "Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides."; J. Biol. Chem. 269:11956-11961. Evidence URLhttps://www.uniprot.org/uniprotkb/BR2F_RANES/entry
RECORD: Rec_0402997 VERIFIED: NO
Provenance & Taxonomy
Rana esculenta [Animal]; Rana ridibunda [Animal]
Structure & Mods
disulfide-stabilized linear peptide [Linear]
canonical L-amino-acid peptide [L]
28-34
Bio-Activity Profile
Antimicrobial
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