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MYP_143294
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Basic Information
BPC184
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C62H111N15O12
Standard
Sequence
KLLLKFKKLQ
Physicochemical Analysis
1258.64 Da
10.48
3.76
3.55
0.3756
-0.11
0.45
-0.14
1.10
156.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
472.39
-0.03
16.0
16.0
48.0
89.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226904 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human pancreatic carcinoma Panc-1
41.5
IC50
PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
RECORD: Rec_0271767 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
A431
24.5±0.7 μM
IC50
PaperAntimicrobial cyclic decapeptides with anticancer activity. Peptides. 2010 Nov;31(11):2017-26. doi: 10.1016/j.peptides.2010.07.027. PMID: 20708052. PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
RECORD: Rec_0279424 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human breast adenocarcinoma MDA-MB-231 80-90% Inhibition
40 μM
PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
RECORD: Rec_0280739 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: 89 ± 5
PaperAntimicrobial cyclic decapeptides with anticancer activity. Peptides. 2010 Nov;31(11):2017-26. doi: 10.1016/j.peptides.2010.07.027. PMID: 20708052. PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
RECORD: Rec_0303353 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Erwinia amylovora PMV 6076
50-75 μM
MIC
PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
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