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MYP_143278
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Basic Information
RI-VEGF-P4(CYC)
Anticancer
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic
Standard
14 amino acids
C69H125N21O19S2
Standard
Sequence
IMRIKQGQIGQMTI
Physicochemical Analysis
1616.99 Da
11.00
1.76
1.55
0.1257
0.10
0.23
0.08
12.66
111.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
679.04
-5.78
23.0
23.0
59.0
111.0
0.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0046038 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF mimetic
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
Acetylation
Literature describes one intramolecular disulfide bond in the CYC construct
N-acetylated retro-inverso / D-amino-acid cyclic VEGF mimetic.
Bio-Activity Profile
Anti-angiogenic Anticancer
Endothelial cells / tumor model
Network formation assay
PaperVEGF peptide mimics and HER2/neu peptide vaccines with anti-angiogenic activity PMID23170253 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23170253/
RECORD: Rec_0108366 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF mimetic
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
Acetylation
Literature describes one intramolecular disulfide bond in the CYC construct
N-acetylated retro-inverso / D-amino-acid cyclic VEGF mimetic.
Bio-Activity Profile
Anti-angiogenic Anticancer
Endothelial cells / tumor model
Endothelial proliferation assay
PaperVEGF peptide mimics and HER2/neu peptide vaccines with anti-angiogenic activity PMID23170253 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23170253/
RECORD: Rec_0224954 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0240501 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Anti-angiogenic
PaperAntiAngioPred: A Server for Prediction of Anti-Angiogenic Peptides PMID26335203 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26335203/
RECORD: Rec_0265446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VEGF mimetic
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
Acetylation
Literature describes one intramolecular disulfide bond in the CYC construct
N-acetylated retro-inverso / D-amino-acid cyclic VEGF mimetic.
Bio-Activity Profile
Anti-angiogenic Anticancer
Endothelial cells / tumor model
Migration assay
PaperVEGF peptide mimics and HER2/neu peptide vaccines with anti-angiogenic activity PMID23170253 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23170253/