Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length109 amino acids

Chemical FormulaC521H890N142O146S6

DescriptionStandard

        KKEGDGMLLRCWLALLVALIPAASSTNAGVKVRLTEKGIEYGKRLGMAALQTKLKSIKVPDISGSKRVMRITNIGLPKSEVDLVPGSGVKLSIGDAYIICSMKNKSFLL
    

Molecular Weight11671.89 Da

Isoelectric Point (pI)9.96

Net Charge (pH 7.0)9.74

Net Charge (pH 7.4) 9.48

Charge Density (pH 7.0) 0.0894

GRAVY Index0.19

Hydrophobic Moment 0.66

Boman Index0.09

Instability Index33.59

Aliphatic Index 114.50

Aromaticity 0.0367

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4628.95

LogP -41.34

H-bond Donors 165.0

H-bond Acceptors 162.0

Rotatable Bonds 406.0

Heavy Atoms 815.0

Ring Count 9.0

Amide Bonds 112.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288873 VERIFIED: NO

Provenance & Taxonomy

OrganismAcanthochromis polyacanthus [Bacterium]

FamilyBPI

Tax ID80966

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence