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MYP_143210
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Basic Information
Buthinin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
34 amino acids
C164H266N60O44S6
Standard
Sequence
SIVPIRCRSNRDCRRFCGFRGGRCTYARQCLCGY
Physicochemical Analysis
3974.63 Da
9.80
6.40
6.10
0.1882
-0.45
0.71
-0.32
66.94
45.88
0.1176
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1734.66
-21.71
72.0
57.0
129.0
274.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024822 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0029130 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
PaperPubMed PMID: 8939880 PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0092896 VERIFIED: NO
Provenance & Taxonomy
Androctonus australis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/; https://www.uniprot.org/uniprotkb/P56685/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0098304 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0151930 VERIFIED: YES
Provenance & Taxonomy
Androctonus australis [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID9287114 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9287114/
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