Peptide Database

Peptide NameBeta-defensin 105A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC395H618N106O106S10

DescriptionStandard

        MALIKKTFFFLFAMFFILVQLSSGCQAGLDFSQPFPSGEFAVCESCKLGRGKCRKECLENEKPDGNCRLNFLCCRQRI
    

Molecular Weight8868.43 Da

Isoelectric Point (pI)8.71

Net Charge (pH 7.0)3.43

Net Charge (pH 7.4) 3.08

Charge Density (pH 7.0) 0.0440

GRAVY Index0.11

Hydrophobic Moment 0.46

Boman Index0.04

Instability Index34.97

Aliphatic Index 72.56

Aromaticity 0.1282

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3427.38

LogP -30.25

H-bond Donors 125.0

H-bond Acceptors 120.0

Rotatable Bonds 299.0

Heavy Atoms 617.0

Ring Count 13.0

Amide Bonds 84.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0217763 VERIFIED: NO

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyDefensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q5IAB6/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0233258 VERIFIED: NO