Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2328H3625N573O675S17

DescriptionStandard

        MIEQMVMEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWEIKSPLFQDTGGANLFLSGVYFTGIIVLALNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMVEVLTKIDNYILLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFLPVPFALPERHDSMLYVGISEFFFKSASFAYFTSGAFNVTLSMKEISNHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPDSFTLDIPASMVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGILPLANAKLQQGIPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSLKQQLSFHGWEGLNLISGQWRGKPVA
    

Molecular Weight50985.22 Da

Isoelectric Point (pI)4.94

Net Charge (pH 7.0)-16.68

Net Charge (pH 7.4) -17.50

Charge Density (pH 7.0) -0.0363

GRAVY Index0.22

Hydrophobic Moment 0.63

Boman Index0.20

Instability Index40.32

Aliphatic Index 106.80

Aromaticity 0.1002

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 35995.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0117856 VERIFIED: NO

Provenance & Taxonomy

OrganismNeomonachus schauinslandi [Animal]

FamilyBPI

Tax ID29088

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence