Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC170H273N49O58

DescriptionStandard

        DEFDASISQVNEKINQSLAFIRKSDELLHNVNAGK
    

Molecular Weight3931.28 Da

Isoelectric Point (pI)4.95

Net Charge (pH 7.0)-2.14

Net Charge (pH 7.4) -2.41

Charge Density (pH 7.0) -0.0613

GRAVY Index-0.59

Hydrophobic Moment 0.65

Boman Index-0.11

Instability Index28.90

Aliphatic Index 92.00

Aromaticity 0.0571

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1784.62

LogP -20.72

H-bond Donors 59.0

H-bond Acceptors 57.0

Rotatable Bonds 138.0

Heavy Atoms 277.0

Ring Count 3.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0369165 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-RSV Entry inhibition

TargetRespiratory syncytial virus (RSV) | HEp-2 cells

Activity3.052 μM

MethodEC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

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