Peptide Database

Peptide NameSLAY-screened peptide P4767

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC95H157N31O25S3

DescriptionStandard

        PGPLRIVNPCHITCCLNKNH
    

Molecular Weight2229.65 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)2.10

Net Charge (pH 7.4) 1.90

Charge Density (pH 7.0) 0.1051

GRAVY Index-0.14

Hydrophobic Moment 0.40

Boman Index0.02

Instability Index69.42

Aliphatic Index 92.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 879.43

LogP -9.36

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 68.0

Heavy Atoms 154.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064215 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/