Peptide Database

Peptide NameSLAY-screened peptide P2335

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H159N27O33S

DescriptionStandard

        YYHTNHAYCDSFKITYEWLP
    

Molecular Weight2551.78 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0538

GRAVY Index-0.77

Hydrophobic Moment 0.37

Boman Index0.08

Instability Index22.57

Aliphatic Index 44.00

Aromaticity 0.3000

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 965.90

LogP -5.05

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 73.0

Heavy Atoms 182.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063429 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/