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MYP_142825
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Basic Information
Ubiquitin-like protein ISG15
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral budding inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Regulatory peptide ▸ Biological modulation
Standard
165 amino acids
C791H1281N221O240S5
Standard
Sequence
MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTEPGGRS
Physicochemical Analysis
17887.29 Da
6.83
-0.23
-0.64
-0.0014
-0.14
0.50
0.05
41.78
96.18
0.0545
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
7398.60
-78.16
254.0
248.0
601.0
1257.0
22.0
180.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0236908 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ISG15
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S-nitrosylation Cys78
Bio-Activity Profile
Antiviral Release inhibition Budding inhibition Anti-HIV-1
Human immunodeficiency virus type-1(HIV-1)
PaperInnate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15. PMID16434471 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16434471/
RECORD: Rec_0361249 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ISG15
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S-nitrosylation Cys78
Bio-Activity Profile
Antiviral Release inhibition Budding inhibition Anti-EBOV
Ebola virus(EBOV)
PaperISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. PMID18305167 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18305167/
RECORD: Rec_0378614 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ISG15
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
S-nitrosylation Cys78
Bio-Activity Profile
Antiviral Replication inhibitor Interferon pathway modulator Anti-IAV
Influenza A virus(IAV)
PaperISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. PMID20133869 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20133869/