Peptide Database

Peptide NameSLAY-screened peptide P4151

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H152N30O32S

DescriptionStandard

        PWTYCTYGTRNNHWDFFSQF
    

Molecular Weight2570.75 Da

Isoelectric Point (pI)7.12

Net Charge (pH 7.0)0.03

Net Charge (pH 7.4) -0.09

Charge Density (pH 7.0) 0.0017

GRAVY Index-1.00

Hydrophobic Moment 0.30

Boman Index0.00

Instability Index15.18

Aliphatic Index 0.00

Aromaticity 0.3500

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1012.34

LogP -8.48

H-bond Donors 38.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 184.0

Ring Count 11.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0328633 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/