Peptide Database

Peptide NameFMRFamide-related peptide type HF-4

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC49H71N15O16

DescriptionStandard

        ENNNGYIRF
    

Molecular Weight1126.18 Da

Isoelectric Point (pI)6.10

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.34

Charge Density (pH 7.0) -0.0182

GRAVY Index-1.43

Hydrophobic Moment 0.37

Boman Index-0.26

Instability Index-17.24

Aliphatic Index 43.33

Aromaticity 0.2222

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 544.82

LogP -6.10

H-bond Donors 18.0

H-bond Acceptors 16.0

Rotatable Bonds 36.0

Heavy Atoms 80.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067407 VERIFIED: NO

Provenance & Taxonomy

OrganismHelix aspersa [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0070146 VERIFIED: NO

Provenance & Taxonomy

OrganismCornu aspersum [Animal]

FamilyENNNGYIRF-amide

Tax ID6535

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0213917 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0389725 VERIFIED: NO

Provenance & Taxonomy

OrganismHelix aspersa [Animal]

FamilyFMRFamide related peptide

Tax ID6535

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator