Peptide Database

Peptide NameSLAY-screened peptide P4400

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC87H144N28O36S2

DescriptionStandard

        PNMPQNSEQSKNSSLSTQNM
    

Molecular Weight2222.37 Da

Isoelectric Point (pI)6.43

Net Charge (pH 7.0)-0.04

Net Charge (pH 7.4) -0.10

Charge Density (pH 7.0) -0.0020

GRAVY Index-1.61

Hydrophobic Moment 0.22

Boman Index-0.31

Instability Index88.19

Aliphatic Index 19.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1079.77

LogP -19.27

H-bond Donors 35.0

H-bond Acceptors 38.0

Rotatable Bonds 76.0

Heavy Atoms 153.0

Ring Count 2.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078909 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/