Peptide Database

Peptide NameBasic phospholipase A2 homolog 2 (svPLA2 homolog) (Myotoxin II) (Basp-II) (Lys49 Mt-II) (MtxII)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Enzyme modulation ▸ Enzyme inhibition ▸ Blood coagulation cascade inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length137 amino acids

Chemical FormulaC678H1089N187O194S17

DescriptionStandard

        MRTLWIMAVLLVGVEGSLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKKLTGCNPKKDRYSYSWKDKTIVCGENNSCLKELCECDKAVAICLRENLNTYNKKYRYYLKPLCKKADAC
    

Molecular Weight15509.14 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)11.45

Net Charge (pH 7.4) 10.92

Charge Density (pH 7.0) 0.0835

GRAVY Index-0.41

Hydrophobic Moment 0.53

Boman Index-0.09

Instability Index22.89

Aliphatic Index 71.90

Aromaticity 0.0949

Extinction Coeff. Reduced 25900.00

Extinction Coeff. Oxidized 26775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6209.34

LogP -58.25

H-bond Donors 231.0

H-bond Acceptors 224.0

Rotatable Bonds 526.0

Heavy Atoms 1076.0

Ring Count 20.0

Amide Bonds 145.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0271550 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops asper [Animal]

FamilyPhospholipase A2; Group II subfamily; K49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Blood coagulation cascade inhibitor Toxin Cytotoxic Non-hemolytic

TargetNo Target Organism Found