Peptide Database

Peptide NameNeurophysin MT

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC417H647N125O140S16

DescriptionStandard

        SVIDFMDVRKCIPCGPRNKGHCFGPNICCGEELGCYFGTTETLRCQEENFLPSPCESGRKPCGNNGGNCARSGICCNHESCTMDPACEQDSVFS
    

Molecular Weight10164.39 Da

Isoelectric Point (pI)5.00

Net Charge (pH 7.0)-4.48

Net Charge (pH 7.4) -5.02

Charge Density (pH 7.0) -0.0477

GRAVY Index-0.44

Hydrophobic Moment 0.64

Boman Index-0.06

Instability Index55.40

Aliphatic Index 40.43

Aromaticity 0.0638

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 2365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4231.18

LogP -57.43

H-bond Donors 155.0

H-bond Acceptors 154.0

Rotatable Bonds 328.0

Heavy Atoms 698.0

Ring Count 15.0

Amide Bonds 102.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0097498 VERIFIED: NO

Provenance & Taxonomy

OrganismBufo japonicus [Animal]

FamilyVasopressin/oxytocin

Tax ID8387

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide11-14

Bio-Activity Profile

Function

Neurohypophyseal hormone Neuropeptide

RECORD: Rec_0257329 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0366151 VERIFIED: YES

Provenance & Taxonomy

OrganismBufo japonicus [Animal]

FamilyMesotocin-neurophysin MT

Tax ID8387

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide11-55; 14-28; 22-45; 29-35; 62-75; 69-87; 76-81

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour