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MYP_142262
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Basic Information
USCL-PCat1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Binding / Molecular interaction ▸ Metal-binding / iron acquisition ▸ Siderophore
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
4 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0059050 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)12CO
Amidation
Ornithine at 1,2,3,4; Ornithine; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 24433
6.25 μg/mL
MIC
PaperSystematic Study of Non-Natural Short Cationic Lipopeptides as Novel Broad-Spectrum Antimicrobial Agents; DOI:10.1111/cbdd.12182 PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0060674 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D or residue-modified peptide [Mixed]
A=amino; l=lauric acid,alK=aminolauryl-lysine; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0065004 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Pcat = L-4R-aminoproline, B = PHyp = L-4R-hydroxyproline at 1,4; non-canonical residue code at 2,3; Pcat = L-4R-aminoproline, B = PHyp = L-4R-hydroxyproline; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
methicillin-resistant Staphylococcus epidermidis CAN-ICU 61589
32 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
RECORD: Rec_0065642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)10CO
Amidation
Ornithine at 1,2,3,4; Ornithine; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Hemolytic
human red blood cells
>250 μg/mL
HC50 / Hemolysis
PaperSystematic Study of Non-Natural Short Cationic Lipopeptides as Novel Broad-Spectrum Antimicrobial Agents; DOI:10.1111/cbdd.12182 PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0066363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Pcat = L-4R-aminoproline, B = PHyp = L-4R-hydroxyproline at 1,4; non-canonical residue code at 2,3; Pcat = L-4R-aminoproline, B = PHyp = L-4R-hydroxyproline; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium ATCC 27270
32 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
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