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MYP_142262
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Basic Information
USCL-PCat1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Binding / Molecular interaction ▸ Metal-binding / iron acquisition ▸ Siderophore
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
4 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXX
Physicochemical Analysis
0.00 Da
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0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0286282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Dab = L-diaminobutyric acid, X = HSe = L-homoserine at 1,4; unspecified non-canonical residue at 2,3; Dab = L-diaminobutyric acid, X = HSe = L-homoserine; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli CAN-ICU 63074
16 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
RECORD: Rec_0289821 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Pcat = L-4R-aminoproline at 1,2,3,4; Pcat = L-4R-aminoproline; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
methicillin-resistant Staphylococcus aureus ATCC 33592
32 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
RECORD: Rec_0294615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Pcat = L-4R-aminoproline, B = PHex = lipophilic proline at 1,4; non-canonical residue code at 2,3; Pcat = L-4R-aminoproline, B = PHex = lipophilic proline; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
512 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
RECORD: Rec_0298983 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Dab = L-diaminobutyric acid at 1,2,3,4; Dab = L-diaminobutyric acid; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
8 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
RECORD: Rec_0301601 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C16
Amidation
Dab = L-diaminobutyric acid, X = HSe = L-homoserine at 1,4; unspecified non-canonical residue at 2,3; Dab = L-diaminobutyric acid, X = HSe = L-homoserine; Contains unresolved X placeholder residue(s)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli CANWARD-2011 97615
8 μg/mL
MIC
PaperStructure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity; DOI:10.1007/s00726-014-1806-z PMID25069750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25069750/
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