MYP_142088
Dynorphin A(1-11)-NH2 analogue 8 (DYN A analogue)
Neurological / Signaling
▸
Analgesic/opioid activity
▸
Endogenous opioid found in CNS
Standard
11 amino acids
C63H103N21O13
Standard
YGGFLRRIRPK
1362.62 Da
11.72
3.76
3.55
0.3416
-0.91
0.45
-0.37
99.68
70.91
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
577.48
-3.78
22.0
17.0
44.0
97.0
3.0
10.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0230612
VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Dynorphin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Incorporating the nonhydrolyzable [CH2-NH] peptide bond surrogate were tested for their in vitro enzymatic stability in mouse brain homogenates.
HPLC
Mouse brain homogenate, in vitro; 11460 s
RECORD: Rec_0292672
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dynorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Addition of hydroxyl group
Bio-Activity Profile
Endogenous opioid found in CNS
LC/MS
plasma, in vitro; 600 s
RECORD: Rec_0328339
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dynorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Endogenous opioid found in CNS
LC/MS
plasma, in vitro; 1800 s