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MYP_141982
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Basic Information
Brevinin-1VLa (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C125H198N28O26S2
Standard
Sequence
FLGAIAGVAAKFLPKVFCFITKKC
Physicochemical Analysis
2573.21 Da
9.70
3.74
3.50
0.1557
1.24
0.57
0.41
10.53
105.83
0.1667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
848.14
-2.38
31.0
32.0
83.0
181.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0377050 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer
Candida albicans
3 μM
MIC
RECORD: Rec_0386502 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer Anti-Gram-positive
Staphylococcus aureus
3 μM
MIC
RECORD: Rec_0390287 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
8000 μM
LC50
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0393209 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
8.0 μM
HC50
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 150 (2009) 150-154. Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
RECORD: Rec_0397278 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
8000 μM
LC50
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
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