Peptide Database

Peptide NameBrevinin-1VLa (Frogs, amphibians, animals)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC125H198N28O26S2

DescriptionStandard

        FLGAIAGVAAKFLPKVFCFITKKC
    

Molecular Weight2573.21 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)3.74

Net Charge (pH 7.4) 3.50

Charge Density (pH 7.0) 0.1557

GRAVY Index1.24

Hydrophobic Moment 0.57

Boman Index0.41

Instability Index10.53

Aliphatic Index 105.83

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 848.14

LogP -2.38

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 83.0

Heavy Atoms 181.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0173917 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide with C-terminal disulfide-stabilized loop [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermFree carboxyl terminus

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus

Activity3 μM

MethodMIC

RECORD: Rec_0177425 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide with C-terminal disulfide-stabilized loop [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermFree carboxyl terminus

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetGram-positive bacteria; Gram-negative bacteria; fungi

MethodMIC antimicrobial susceptibility assay

RECORD: Rec_0191222 VERIFIED: NO

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

Structure & Mods

Configlinear peptide with C-terminal disulfide-stabilized loop [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermFree carboxyl terminus

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0243518 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide with C-terminal disulfide-stabilized loop [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermFree carboxyl terminus

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic Anticancer

TargetHepG2 hepatoma-derived cells

Activity≤8 μM

MethodLC50 (cell cytotoxicity)

RECORD: Rec_0262918 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide with C-terminal disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

C-TermFree carboxyl terminus

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity25.0 μM

MethodMIC

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