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MYP_141982
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Basic Information
Brevinin-1VLa (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
24 amino acids
C125H198N28O26S2
Standard
Sequence
FLGAIAGVAAKFLPKVFCFITKKC
Physicochemical Analysis
2573.21 Da
9.70
3.74
3.50
0.1557
1.24
0.57
0.41
10.53
105.83
0.1667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
848.14
-2.38
31.0
32.0
83.0
181.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000624 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
RECORD: Rec_0044253 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer Anti-Gram-negative
Escherichia coli
25 μM
MIC
RECORD: Rec_0076200 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anticancer
erythrocytes
4-8 μM
LC50
RECORD: Rec_0133034 VERIFIED: YES
Provenance & Taxonomy
Lithobates vaillanti [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 150 (2009) 150-154. Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
RECORD: Rec_0151860 VERIFIED: YES
Provenance & Taxonomy
Rana vaillanti [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
3 μM
MIC
PMID19379837 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19379837/
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