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MYP_141791
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Basic Information
Defensin 3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
32 amino acids
C146H250N58O45S6
Standard
Sequence
RTCRCRLGRCSRRESYSGSCNINGRIYSLCCR
Physicochemical Analysis
3730.30 Da
9.80
6.70
6.41
0.2094
-0.73
0.67
-0.47
58.85
48.75
0.0625
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1745.94
-25.95
74.0
58.0
126.0
255.0
2.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125461 VERIFIED: NO
Provenance & Taxonomy
Hamadryas baboon [Animal]; Mammalia [Animal]
33208; 40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0138627 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
PaperPubMed PMID: 16978151 PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
RECORD: Rec_0160795 VERIFIED: YES
Provenance & Taxonomy
Papio anubis [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0169134 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
the Gram- bacterium Escherichia coli
2.0 μM
MIC
Paperalpha-Defensins from blood leukocytes of the monkey Papio hamadryas
RECORD: Rec_0175071 VERIFIED: YES
Provenance & Taxonomy
Papio hamadryas [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID16978151 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16978151/
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