Peptide Database

Peptide NameTyrocidine B1, TrcB1

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC69H92N14O14

DescriptionStandard

        VKLFPWFNQY
    

Molecular Weight1341.55 Da

Isoelectric Point (pI)8.56

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.52

Charge Density (pH 7.0) 0.0732

GRAVY Index-0.11

Hydrophobic Moment 0.41

Boman Index0.26

Instability Index-1.07

Aliphatic Index 68.00

Aromaticity 0.4000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 464.65

LogP 0.40

H-bond Donors 15.0

H-bond Acceptors 15.0

Rotatable Bonds 38.0

Heavy Atoms 97.0

Ring Count 6.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351370 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus aneurinolyticus,Bacillus brevis [Bacterium]

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitymixed L/D or modified amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Other Modsf=D-Phe

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetHeLa

Activity28 μM

MethodLC50

RECORD: Rec_0367811 VERIFIED: YES