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MYP_141740
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Basic Information
A4K14-citropin1.1-Sp7
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
16 amino acids
C76H134N22O19
Standard
Sequence
GLFAVRKKVASVSKGL
Physicochemical Analysis
1660.01 Da
11.26
3.76
3.55
0.2348
0.50
0.47
0.09
-1.24
115.62
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
680.24
-6.09
25.0
23.0
58.0
117.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
7.47 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616148. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0095858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
A549
16.37 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616148. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0198027 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
12.1 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616148. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0263515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116
7.44 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616148. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0346920 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer Antimicrobial Antibacterial
U-87MG ATCC
9.2 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616148. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
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