Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length108 amino acids

Chemical FormulaC544H888N146O143S6

DescriptionStandard

        MFLCCWLVLGALLSINPGVKVRLTEKGIEYGKVCVKAQKLNSIQVPDFSGEQRVSPIGKVQYNFIRVLKVGIPKSSVDLVPGTGVRMSIGDAFISLNGNWRVKYLRIM
    

Molecular Weight11954.15 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)8.47

Net Charge (pH 7.4) 8.19

Charge Density (pH 7.0) 0.0784

GRAVY Index0.28

Hydrophobic Moment 0.67

Boman Index0.13

Instability Index12.13

Aliphatic Index 112.59

Aromaticity 0.0833

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4644.83

LogP -36.88

H-bond Donors 164.0

H-bond Acceptors 158.0

Rotatable Bonds 401.0

Heavy Atoms 839.0

Ring Count 16.0

Amide Bonds 116.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0098272 VERIFIED: NO

Provenance & Taxonomy

OrganismMaylandia zebra [Bacterium]

FamilyBPI

Tax ID106582

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence