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MYP_141717
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Basic Information
T1988(FIV envelope protein (737-771))
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
35 amino acids
C188H300N52O59S
Standard
Sequence
NQTKDLQQKFYEIIMDIEQNNVQGKKGIQQLQKWE
Physicochemical Analysis
4264.77 Da
6.36
-0.23
-0.45
-0.0066
-1.28
0.67
-0.23
60.64
75.14
0.0857
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1899.56
-17.94
60.0
60.0
155.0
300.0
4.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0083558 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Feline immunodeficiency virus (FIV):inhibition of cell-cell fusion between FIV/CrFK cells and HeLa cells
1.99 μM
EC50
PaperPubMed PMID: 12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0217842 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cell-cell fusion between CEM4/IIIb cells and MOLT4 cells
2.322 μM
EC50
PaperPubMed PMID: 12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0219463 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CEM4/IIIb cells; MOLT4 cells
2.322 μM
EC90
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0264652 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline immunodeficiency virus (FIV)
>2.322 μM
IC90
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0270691 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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