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MYP_141666
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Basic Information
Puroindoline-A (34-46)[F1R,P2K,V3r,T4W,G13R]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C108H146N34O14
Standard
Sequence
RKRWWRWWKWWKR
Physicochemical Analysis
2144.53 Da
12.00
6.76
6.55
0.5198
-2.70
0.76
-0.75
147.51
0.00
0.4615
33000.00
33000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
832.92
1.00
35.0
21.0
65.0
156.0
12.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173401 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
NIH 3T3
250 μg/mL
IC50
PMID33207639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33207639/
RECORD: Rec_0252778 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans FRR 5580
64 μg/mL
MIC
PMID33207639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33207639/
RECORD: Rec_0276203 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human cervical carcinoma HeLa
32 μg/mL
IC50
PMID33207639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33207639/
RECORD: Rec_0321467 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa
32 μg/mL
IC50
PMID33207639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33207639/
RECORD: Rec_0331987 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
r=D-Arg; w=D-Trp
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa
125 μg/mL
IC50
PMID33207639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33207639/
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