Peptide Database

Peptide NamedC4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC111H178N34O23

DescriptionStandard

        FIHHIIGGLFSAGKAIHRLIR
    

Molecular Weight2356.81 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.02

Net Charge (pH 7.4) 2.66

Charge Density (pH 7.0) 0.1438

GRAVY Index0.70

Hydrophobic Moment 0.89

Boman Index0.29

Instability Index44.03

Aliphatic Index 139.52

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 901.41

LogP -4.62

H-bond Donors 33.0

H-bond Acceptors 29.0

Rotatable Bonds 78.0

Heavy Atoms 168.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353650 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Antifungal

PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/

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