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MYP_141664
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Basic Information
dC4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C111H178N34O23
Standard
Sequence
FIHHIIGGLFSAGKAIHRLIR
Physicochemical Analysis
2356.81 Da
12.00
3.02
2.66
0.1438
0.70
0.89
0.29
44.03
139.52
0.0952
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
901.41
-4.62
33.0
29.0
78.0
168.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007649 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Hemolytic
mouse red blood cells
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0010220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
mouse red blood cells
25 μg/mL
Hemolysis
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0057399 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Methicillin-resistant Staphylococcus aureus
256 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0063201 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
128 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0083210 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus
64 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
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